All the people in this countryside area, can count on Jean-Pierre, the doctor who auscultates them, heals and reassures them day and night, 7 days a week. Now Jean-Pierre is sick, so he sees Natalie, a young doctor, coming from the hospital to assist him. But will she adapt to this new life and be able to replace the man that believed to be irreplaceable?
At a tiny Parisian café, the adorable yet painfully shy Amélie (Audrey Tautou) accidentally discovers a gift for helping others. Soon Amelie is spending her days as a matchmaker, guardian angel, and all-around do-gooder. But when she bumps into a handsome stranger, will she find the courage to become the star of her very own love story?